Vine™ Solution
The Clinical Challenge
Patients with Atrial Fibrillation who experience ischemic stroke remain at high risk of recurrence1–3.
Although long-term OAC, including DOACs and VKAs, is effective, the risk of recurrent stroke nevertheless remains high4–7. This highlights a significant unmet need.
2. Seiffge DJ, De Marchis GM, Koga M, et al. Ischemic Stroke despite Oral Anticoagulant Therapy in Patients with Atrial Fibrillation. Ann Neurol. 2020; 87:677-687.
3. Tanaka K, Koga M, Lee KJ, et al. Atrial Fibrillation-Associated Ischemic Stroke Patients With Prior Anticoagulation Have Higher Risk for Recurrent Stroke. Stroke. 2020; 51:1150-1157.
4. Diener HC, Connolly SJ, Ezekowitz MD, et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial. Lancet Neurol. 2010; 9:1157-1163.
5. Easton JD, Lopes RD, Bahit MC, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012; 11:503-511.
6. Hankey GJ, Patel MR, Stevens SR, et al. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol. 2012; 11:315-322.
7. Rost NS, Giugliano RP, Ruff CT, et al. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events: Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48). Stroke. 2016; 47:2075-2082.
A New Treatment Paradigm
The permanent Vine™ Filter is designed to capture emboli capable of causing anterior large vessel occlusion (LVO) stroke before they reach the anterior cerebral circulation.
Target Patient Population
Patients may be eligible if they have:
Atrial Fibrillation
A history of ischemic stroke within the past year
Planned or existing use of OAC
Simple Deployment Procedure
Seamless Clinical Integration
The Vine™ Filter is implanted by trained physicians and designed to integrate into existing clinical workflows with minimal disruption.
The procedure may be performed:
- At the bedside
- In the cath lab
- In a surgical suite
Implantation typically takes less than 30 minutes.
Who Performs the Procedure?
The Vine™ Filter is implanted by trained physicians, including:
- Interventional neuroradiologists
- Vascular surgeons
- Interventional radiologists
- Cardiac electrophysiologists
- Interventional cardiologists
Help advance the future of stroke prevention
Investigational device, limited by United States law to investigational use.